North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group

5 Infections

Please note that Primary and Secondary Care have separate antimicrobial guidelines; Secondary Care utilises a UHNM Trust-specific antimicrobial formulary (note that the UHNM antimicrobial guidelines [microguide] can also be downloaded on smartphones).

These can be found at:

For Primary Care, the Antimicrobial Guidelines can be accessed on netFormulary link:

For Secondary Care on the UHNM intranet by following: http://uhnm/clinicians/clinical-guidance/clinical-guidelines-and-pathways/antimicrobial/

Patients with HIV are treated according to the NICE accredited British HIV Association (BHIVA) guidelines which can be found at

05-01-07 Some other antibacterials

Colistimethate injection for nebuliser Colomycin®

Colistimethate Sodium Injection 500,000u Vl (Dry)
Colistimethate Sodium Injection 1,000,000u Vl (Dry) 
Colistimethate Sodium Injection 2,000,000u Vl (Dry) 

Restriction: Non-CF Bronchiectasis. 1st line

Treatment by Inhalation not IV.
Note Colomycin® Injection may be used for nebulisation; administer required dose in 2-4 mL of sodium chloride 0.9%, (or water for injections) or a 1:1 mixture of sodium chloride 0.9% and water for injection.

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Colistimethate Promixin®

Promixin 1,000,000u powder for nebuliser solution UDV
Promixin 1,000,000u powder for solution for injection vials

Restriction: Non-CF Bronchiectasis. 2nd Line only at the recommendation of respiratory consultant

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Colistimethate dry powder for nebuliser Colobreathe®

Colobreathe 1,662,500u inhalation powder capsules.


  • CF - In line with NICE Guidance & in accordance with NHS England prescribing policy. This is an NHS England Specialised Commissioning Drug for Cystic Fibrosis.


  • Non-CF Bronchiectasis. 3rd line only. Prior approval is required from CCG. Respiratory consultant prescription only.
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin

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Rifaximin Targaxan®

Rifaximin Tablets 550mg

Restriction: In line with NICE Guidance. To be initiated by a gastroenterologist only

Specialist use only for reduction in recurrence of hepatic encephalopathy

Link  NICE TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy

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