North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group

 
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5 Infections

Please note that Primary and Secondary Care have separate antimicrobial guidelines; Secondary Care utilises a UHNM Trust-specific antimicrobial formulary (note that the UHNM antimicrobial guidelines [microguide] can also be downloaded on smartphones).

These can be found at:

For Primary Care, the Antimicrobial Guidelines can be accessed on netFormulary link: http://www.northstaffordshirejointformulary.nhs.uk/docs/misc/Antimicrobial%20guidelines%202019%20Final%20version.pdf

For Secondary Care on the UHNM intranet by following: http://uhnm/clinicians/clinical-guidance/clinical-guidelines-and-pathways/antimicrobial/

Patients with HIV are treated according to the NICE accredited British HIV Association (BHIVA) guidelines which can be found at www.bhiva.org

05-03-03-02 Chronic hepatitis C

All medicines for the treatment of viral hepatitis are funded by NHS England


Boceprevir Victrelis®
Formulary

Boceprevir Capsules 200mg

Restriction: In line with NICE Guidance
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Boceprevir is no longer available in the UK 

Link  NICE TA253: Boceprevir for the treatment of genotype 1 chronic hepatitis C
 

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Daclatasvir  Daklinza®
Formulary

Daclatasvir Tablets 30mg
Daclatasvir Tablets 60mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
This is an NHS England Specialised Commissioning Drug for Hepatitis C

 

MHRA/CHM advice: Direct-acting antivirals to treat chronic hepatitis C: risk of interaction with vitamin K antagonists and changes in INR (January 2017)

MHRA/CHM advice: Direct-acting antiviral interferon-free regimens to treat chronic hepatitis C: risk of hepatitis B reactivation (January 2017)

MHRA/CHM advice: Direct-acting antivirals for chronic hepatitis C: risk of hypoglycaemia in patients with diabetes (December 2018)

Bristol-Myers Squibb has discontinued daclatasvir (Daklinza)

Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
 

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Dasabuvir Sodium Monohydrate Exviera®
Formulary

Dasabuvir Tablets 250mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
This is an NHS England Specialised Commissioning Drug for Hepatitis C

 

MHRA/CHM advice: Direct-acting antivirals to treat chronic hepatitis C: risk of interaction with vitamin K antagonists and changes in INR (January 2017)

MHRA/CHM advice: Direct-acting antiviral interferon-free regimens to treat chronic hepatitis C: risk of hepatitis B reactivation (January 2017)

MHRA/CHM advice: Direct-acting antivirals for chronic hepatitis C: risk of hypoglycaemia in patients with diabetes (December 2018)

Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
 

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Elbasvir & Grazoprevir Zepatier®
Formulary

Elbasvir & Grazoprevir Tablets 50/100mg

Restriction: In line with NICE Guidance
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
 

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Glecaprevir & Pibrentasvir Maviret®
Formulary

Glecaprevir & Pibrentasvir Tablets 100/40mg

Restriction: In line with NICE Guidance
NHS England Commissioned

Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
 

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Ledipasvir & Sofosbuvir Harvoni®
Formulary

Ledipasvir & Sofosbuvir Tablets 90/400mg

Restriction: In line with NICE Guidance
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Link  NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
 

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Ombitasvir, paritaprevir & ritonavir Viekirax®
Formulary

Ombitasvir, paritaprevir & ritonavir Tablets 12.5/75/50mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
 

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Ribavirin
Formulary

Ribavirin Tablets 200mg
Ribavirin Tablets 400mg
Ribavirin Capsules 200mg
Ribavirin Oral Solution 40mg/ml
Ribavirin Injection 1.2g/12ml vials

Restriction: In line with NICE Guidance
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Link  NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
 

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Simeprevir Olysio®
Formulary

Simeprevir Capsules 150mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
NHS England commissioned

Simeprevir Discontinued

Link  NICE TA331: Simeprevir with peginterferon alfa & ribavirin for hepatitis C
 

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Sofosbuvir Sovaldi®
Formulary

Sofosbuvir Tablets 400mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
NHS England commissioned

Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
 

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Sofosbuvir & Velpatasvir Epclusa®
Formulary

Sofosbuvir & Velpatasvir Tablets 400/100mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
This is an NHS England Specialised Commissioning Drug for Hepatitis C

 

Link  NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
 

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Sofosbuvir, velpatasvir & voxilaprevir Vosevi®
Formulary

Sofosbuvir, velpatasvir & voxilaprevir Tablets 400/100/100mg

Restriction: In line with NICE Guidance
NHS England commissioned

 

Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
 

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Telaprevir Incivo®
Formulary

Telaprevir Tablets 375mg

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policy
This is an NHS England Specialised Commissioning Drug for Hepatitis C

Telaprevir no longer has a marketing authorisation in the UK 

Link  NICE TA252: Telaprevir in hepatitis C
 

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