North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group

 
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4 Central nervous system
04-02-03 Drugs used for mania and hypomania

Carbamazepine
Formulary

Carbamazepine Tablets 100mg
Carbamazepine Tablets 200mg
Carbamazepine Tablets 400mg
Carbamazepine MR Tablets 200mg
Carbamazepine MR Tablets 400mg
Carbamazepine Suppositories 125mg
Carbamazepine Suppositories 250mg
Carbamazepine Oral Solution 100mg/5ml

Restriction: Initiation by psychiatrist

Suppositories of 125 mg may be considered to be approximately equivalent in therapeutic effect to tablets of 100 mg but final adjustment should always depend on clinical response (plasma concentration monitoring recommended).


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Lithium Carbonate Prescribe by brand
Formulary

Prescribe by Brand and maintain patient on the same Brand

Current Brands Available:
Camcolit, Lithonate, Liskonum and Priadel Tablets

Restriction: Initiation by psychiatrist

Note change in bioavailability when changing from Tablets to Liquid. Note Lithium citrate tetrahydrate 520 mg (liquid) is equivalent to lithium carbonate 204 mg (tablet).

Preparations vary widely in bioavailability; changing the preparation requires the same precautions as initiation of treatment (Lithium Carbonate)

Link to ESCA


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Lithium Citrate
Formulary

Prescribe by Brand and maintain patient on the same Brand

Current Brands Available:
Priadel Liquid and Li-liquid

Restriction: Initiation by psychiatrist

Note change in bioavailability when changing from Tablets to Liquid. Note Lithium citrate tetrahydrate 520 mg (liquid) is equivalent to lithium carbonate 204 mg (tablet).

Preparations vary widely in bioavailability; changing the preparation requires the same precautions as initiation of treatment (Lithium Carbonate).

Link to ESCA


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Valproic Acid Depakote®
Formulary

Valproic Acid Tablet EC 250mg (As Semisodium Valproate)
Valproic Acid Tablet EC 500mg (As Semisodium Valproate)

Restriction: Initiation by psychiatrist

Contraindicated in women of childbearing potential unless part of the Pregnancy Prevention Programme (MHRA, March 2018).

Women of Childbearing Potential: Educational Risk Minimisation Materials

Patient Card – to be given by pharmacists to all female patients who are dispensed valproate medicines to inform them of the risks

Link  MHRA Guidance on Valproate use by women and girls
 

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