North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group

 
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4 Central nervous system
04-03-03 Selective serotonin re-uptake inhibitors

Citalopram
Formulary

Citalopram Hydrobromide Tablet 10mg 
Citalopram Hydrobromide Tablet 20mg 
Citalopram Hydrobromide Tablet 40mg 
Citalopram (as Citalopram Hydrochloride) Oral Drops 40mg/ml S/F 

Cost effective choice in patients where QT interval prolongation is not an issue (see MHRA advice below for detail) Maximum daily dose 40 mg for adults; 20 mg for patients older than 65 years; and 20 mg for those with hepatic impairment. 

Link  MHRA Guidance on Citalopram and Escitalopram: QT Interval prolongation
 

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Fluoxetine
Formulary

Fluoxetine (as Fluoxetine Hydrochloride) Capsule 20mg
Fluoxetine (as Fluoxetine Hydrochloride) Liquid 20mg/5ml (Prescribe Liquid for doses less than 20mg)

1st line SSRI for depression


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Paroxetine
Formulary

Paroxetine (as Paroxetine Hydrochloride) Tablet 20mg 
Paroxetine (as Paroxetine Hydrochloride) Tablet 30mg 
Paroxetine (as Paroxetine Hydrochloride) Oral Suspension 10mg/5ml SF

Concern noted due to problems with discontinuation- Associated with a higher risk of withdrawal reactions

 


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Sertraline
Formulary

Sertraline (as Sertraline hydrochloride) Tablet 50mg
Sertraline (as Sertraline hydrochloride) Tablet 100mg 


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Vortioxetine
Formulary

Vortioxetine 5mg Tablets
Vortioxetine 10mg Tablets
Vortioxetine 20mg Tablets

Restriction: In line with NICE Guidance

Vortioxetine is recommended as an option for treating major depressive episodes in adults whose condition has responded inadequately to 2 antidepressants within the current episode.

Link  NICE TA367 - Vortioxetine for treating major depressive episodes
 

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Escitalopram
Restricted

Not approved for inclusion in the North Staffordshire Joint Formulary

 

 

 


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