North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group

4 Central nervous system
04-06 5HT3 antagonists


Ondansetron (as Ondansetron hydrochloride) Tablets 4mg
Ondansetron (as Ondansetron hydrochloride) Tablets 8mg
Ondansetron (as Ondansetron hydrochloride) Injection 4mg/2ml Amps
Ondansetron Orodispersible film 4mg (Prescribe as Setofilm®)
Ondansetron Orodispersible film 8mg (Prescribe as Setofilm®)

1st Line in secondary care

If patient has swallowing difficulties the most cost effective option for both 4mg and 8mg strength are the Setofilm® orodisperible films as the liquid and generically prescribed orodispersible tablets and melts are more expensive. These must be prescribed by brand Setofilm®.

MHRA advice: Ondansetron- small increased risk of oral clefts following use in the first 12 weeks of pregnancy (Jan 2020)

Green View adult BNF  View SPC online  View childrens BNF
Palonosetron & netupitant Akynzeo®

Netupitant/ Palonosetron Capsules 300mg/0.5mg 

Restriction: For the prevention of nausea and vomiting in highly emetogenic chemotherapy regimens

Red View adult BNF  View SPC online  View childrens BNF

Not approved for inclusion in the North Staffordshire Joint Formulary


Restricted Drug Grey View adult BNF  View SPC online  View childrens BNF