netFormulary NHS
North Staffordshire Joint Formulary
North Staffordshire Clinical Commissioning Group
Stoke-on-Trent Clinical Commissioning Group
 Search
 Formulary Chapter 10: Musculoskeletal and joint diseases - Full Chapter
10.01  Expand sub section  Drugs used in rheumatic diseases and gout
10.01.01  Expand sub section  Non-steroidal anti-inflammatory drugs
Ibuprofen 
View adult BNF View SPC online View childrens BNF  Track Changes
First Choice
Green

1st line NSAID

Ibuprofen 200mg tablets
Ibuprofen 400mg tablets
Ibuprofen 100mg/5ml oral suspension
Ibuprofen 100mg/5ml oral suspension SF

 
Diclofenac 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Diclofenac 25mg E/C tablet
Diclofenac 50mg E/C tablet
Diclofenac 50mg tablet
Diclofenac 75mg MR tablet and capsule
Diclofenac 100mg MR tablet and capsule
Diclofenac 12.5mg suppositories
Diclofenac 25mg suppositories
Diclofenac 50mg suppositories
Diclofenac 100mg suppositories
Diclofenac 75mg/3ml solution for injection ampoules

Diclofenac is now contraindicated in those with: ischaemic heart disease; peripheral arterial disease; cerebrovascular disease; or established congestive heart failure (New York Heart Association [NYHA] classification II-IV). Naproxen and ibuprofen are preferred when NSAIDs are indicated. 

 
Link  MHRA Guidance on Diclofenac
   
Diclofenac 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Diclofenac 25mg E/C tablet
Diclofenac 50mg E/C tablet
Diclofenac 50mg tablet
Diclofenac 75mg MR tablet and capsule
Diclofenac 100mg MR tablet and capsule
Diclofenac 12.5mg suppositories
Diclofenac 25mg suppositories
Diclofenac 50mg suppositories
Diclofenac 100mg suppositories
Diclofenac 75mg/3ml solution for injection ampoules

 

Paediatrics only

 
Link  Medicines For Children: Diclofenac for pain and inflammation
   
Indometacin 
(Indomethacin)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Indometacin 25mg capsules
Indometacin 50mg capsules

 

If an NSAID is needed, use ibuprofen (1200mg a day or less) or naproxen (1000mg a day or less)

 

 

 
   
Meloxicam 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Meloxicam 7.5mg tablets
Meloxicam 15mg tablets

 

If an NSAID is needed, use ibuprofen (1200mg a day or less) or naproxen (1000mg a day or less)

 
   
Nabumetone 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Nabumetone 500mg tablets

 

If an NSAID is needed, use ibuprofen (1200mg a day or less) or naproxen (1000mg a day or less).

 
   
Naproxen 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Naproxen 250mg tablets
Naproxen 500mg tablets

Standard release preparations only

 

 
   
Celecoxib 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Celecoxib 100mg capsules
Celecoxib 200mg capsules

 

If an NSAID is needed, use ibuprofen (1200mg a day or less) or naproxen (1000mg a day or less)

MHRA Advice: COX-2 NSAIDs have a higher cardiovascular risk profile

 
Link  MHRA Guidance on cardiovascular safety of Cox-2 inhibitors
   
10.01.02  Expand sub section  Corticosteroids
10.01.02.01  Expand sub section  Systemic corticosteroids
Prednisolone 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Prednisolone 1mg tablets
Prednisolone 5mg tablets

 
   
10.01.02.02  Expand sub section  Local corticosteroids injections to top
Hydrocortisone acetate
(Hydrocortistab®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Hydrocortistab® - Hydrocortisone acetate 25mg/1ml suspension for injection ampoules

MHRA/CHM advice: Corticosteroids: rare risk of central serous chorioretinopathy with local as well as systemic administration (August 2017)

 
   
Methylprednisolone acetate
(Depo-Medrone®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Depo-Medrone®- Methylprednisolone acetate 40mg/1ml suspension for injection vials (1ml, 2ml AND 3ml vial)

MHRA/CHM advice: Corticosteroids: rare risk of central serous chorioretinopathy with local as well as systemic administration (August 2017)

 
   
Triamcinolone acetonide
(Adcortyl®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Adcortyl® - Intra-articular/Intradermal triamcinolone acetonide 10mg/1ml suspension for injection ampoules
Kenalog®  - Intra-articular/Intradermal triamcinolone acetonide 10mg/1ml suspension for injection vials

For doses below 5 mg use Adcortyl®; for larger doses greater than 15mg, use Kenalog®.

MHRA/CHM advice: Corticosteroids: rare risk of central serous chorioretinopathy with local as well as systemic administration (August 2017)

 
   
10.01.03  Expand sub section  Drugs which suppress the rheumatic disease process
Mycophenolate mofetil

View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Mycophenolate mofetil 250mg capsules
Mycophenolate mofetil 500mg tablets
Mycophenolate mofetil 200mg per 1ml oral suspension

MHRA/CHM advice: Mycophenolate mofetil, mycophenolic acid: updated contraception advice for male patients (February 2018)

Link to ESCA (for rheumatology pts)

 
   
10.01.03  Expand sub section  Gold
Sodium aurothiomalate
(Myocrisin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Myocrisin®Sodium aurothiomalate 20mg/1ml solution for injection ampoules
Myocrisin®Sodium aurothiomalate 100mg/1ml solution for injection ampoules 

 

DISCONTINUATION

Sanofi has confirmed the discontinuation of 10mg, 20mg and 50mg ampoules of Myocrisin from 30th June 2019 (being 3 months from the shortest expiry date). There are supplies within the supply chain, and will continue until current stock is depleted.

 

 
   
10.01.03  Expand sub section  Penicillamine
Penicillamine 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Penicillamine 125mg tablets
Penicillamine 250mg tablets

Amber E For autoimmune rheumatic diseases

Link to ESCA

 
   
10.01.03  Expand sub section  Antimalarials
Chloroquine (Avloclor®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Avloclor® - Chloroquine phosphate 250mg tablets

 

 
   
Hydroxychloroquine sulfate

View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Hydroxychloroquine sulfate 200mg tablets

(Rheumatology)

Link to ESCA

 
   
10.01.03  Expand sub section  Drugs affecting the immune response to top
Cytotoxic Drug Azathioprine 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Azathioprine 25mg tablets
Azathioprine 50mg tablets

Link to ESCA

 
   
Ciclosporin (Prescribe by brand)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Ciclosporin 10mg capsules (only available as Neoral®)
Ciclosporin 25mg capsules
Ciclosporin 50mg capsules
Ciclosporin 100mg capsules

MHRA/CHM advice: ciclosporin must be prescribed and dispensed by brand name (December 2009)

Link to ESCA

 
   
Leflunomide 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Leflunomide 10mg tablets
Leflunomide 20mg tablets

Link to ESCA

 

 

 
   
Cytotoxic Drug Methotrexate 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Methotrexate 2.5mg tablets
Methotrexate injection (as pre-filled syringes/ pens/ injectors)- brands include Nordimet®, Zlatal®, Methofill® and Metoject PEN®

Prescribe WEEKLY (on the same day each week); orally as multiples of 2.5mg strength tablets.

Link to ESCA

MHRA/CHM advice: Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing (September 2020)

 
   
10.01.03  Expand sub section  Cytokine modulators
Abatacept (Orencia®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 
Link  NICE TA195: Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor
Link  NICE TA373: Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis
Link  NICE TA375: Rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
   
Adalimumab (Hyrimoz®, Amgevita®, Imraldi®, Hulio®, Humira®(Prescribe by brand)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

Clinicians must ensure the biosimilar brand for their region is prescribed first-line.
(Hyrimoz is the first line biosimilar in West Midlands region; Amgevita is used in patients intolerant to citrate content i.e injection site reactions)

 
Link  UKMI: Adalimumab Biosimilar Comparison
Link  NICE TA195: Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor
Link  NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
Link  NICE TA373: Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Anakinra (Kineret®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

Not routinely commissioned by NHS England for adult and paediatric indications except by prior IFR approval. Commissioned by NHS England for cryopyrin associated periodic syndrome -highly specialised criteria only.

 
Link  NICE NG100: Rheumatoid arthritis in adults: management
   
Apremilast (Otezla®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 
Link  NICE TA433 : Apremilast for treating active psoriatic arthritis
   
Belimumab (Benlysta® )Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 

MHRA advice (May 2019):Belimumab (Benlysta▼)- increased risk of serious psychiatric events seen in clinical trials

 
Link  NICE TA397: Belimumab for treating active autoantibody-positive systemic lupus erythematosus
   
Certolizumab Pegol (Cimzia®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
Link  NICE TA415: Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitor
Link  NICE TA445 : Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARD
Link  NICE TA574: Certolizumab pegol for treating moderate to severe plaque psoriasis
   
Etanercept (Enbrel®, Benepali®, Erelzi®)
(Prescribe by brand)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 

 

 
Link  NICE TA195: Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor
Link  NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
Link  NICE TA373: Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Golimumab (Simponi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 
Link  NICE TA220: Golimumab for the treatment of psoriatic arthritis
Link  NICE TA225: Golimumab for the treatment of rheumatoid arthritis after the failure of previous disease-modifying anti-rheumatic drugs
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
Link  NICE TA497: Golimumab for treating non-radiographic axial spondyloarthritis
   
Infliximab (Flixabi®, Inflectra®, Remicade®, Remsima®)
(Prescribe by brand)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 

Not routinely commissioned by NHS England for Connective tissue disease, interstital lung disease, renal or sarcoidosis except by prior IFR approval.

 
Link  NICE TA195: Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor
Link  NICE TA199: Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Ixekizumab (Taltz® )Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
BlueTeq

Restriction: In line with NICE Guidance

 
Link  NICE TA537: Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDs
   
Rituximab (MabThera®, Rixathon®, Truxima®)Black Triangle
(Prescribe by brand)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 

Not routinely commissioned by NHS England for connective tissue disease (interstitial lung disease), primary Sjorgren's disease or chronic inflammatory demyelinating polyneuropathy except by prior IFR approval.

 
Link  NICE TA195: Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor
   
Secukinumab (Cosentyx®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance

Restriction: In accordance with NHS England prescribing policies

 

Not routinely commissioned by NHS England for paediatric indications except by prior IFR approval.

 
Link  NICE TA407: Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitors
Link  NICE TA445: Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs
   
Tocilizumab (RoActemra®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Restriction: In line with NICE Guidance 

Restriction: In accordance with NHS England prescribing policies

 

MHRA advice(July 2019): Rare risk of serious liver injury including cases requiring transplantation.

 
Link  NICE TA238: Tocilizumab for the treatment of systemic juvenile idiopathic arthritis
Link  NICE TA247:Tocilizumab for the treatment of rheumatoid arthritis
Link  NICE TA373: Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis
Link  NICE TA375: Adalimumab, etanercept, infliximab, certolizumab pegol,golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Link  NICE TA518: Tocilizumab for treating giant cell arteritis
   
Sarilumab (Kevzara®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
BlueTeq

Restriction: In line with NICE Guidance

 
Link  NICE TA485: Sarilumab for moderate to severe rheumatoid arthritis
   
Baricitinib (Olumiant®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
BlueTeq

Restriction: In line with NICE Guidance

MHRA/CHM advice: Baricitinib (Olumiant®): risk of venous thromboembolism (March 2020)

MHRA/CHM advice: Baricitinib (Olumiant®): increased risk of diverticulitis, particularly in patients with risk factors (August 2020)

 
Link  MHRA drug safety update: Baricitinib (Olumiant): risk of venous thromboembolism
Link  NICE TA466: Baricitinib for moderate to severe rheumatoid arthritis
   
Tofacitinib  (Xeljanz®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance

 
Link  MHRA drug safety update: Tofacitinib (Xeljanz): new measures to minimise risk of venous thromboembolism and of serious and fatal infections
Link  NICE TA480: Tofacitinib for moderate to severe rheumatoid arthritis
Link  NICE TA543: Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs
   
Upadacitinib (Rinvoq®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
CCG
BlueTeq

Restriction: In line with NICE Guidance

MHRA/CHM advice: Baricitinib (Olumiant®): risk of venous thromboembolism (March 2020) (Upadacitinib)

 
Link  MHRA Drug Safety Update: Baricitinib (Olumiant▼)/ Upadacitinib risk of venous thromboembolism
Link  NICE TA665: Upadacitinib for treating severe rheumatoid arthritis
   
10.01.03  Expand sub section  Sulfasalazine
Sulfasalazine (Salazopyrin EN-Tabs)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Sulfasalazine gastro resistant 500mg tablets

Please note only the gastro resistant tablets are licensed for treatment of active rheumatoid arthritis.

Link to ESCA

 

 
   
10.01.04  Expand sub section  Gout and cytotoxic-induced hyperuricaemia
10.01.04  Expand sub section  Acute attacks of gout
Colchicine 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Colchicine 500microgram tablets

 
   
10.01.04  Expand sub section  Long-term control of gout to top
Allopurinol 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Allopurinol 100mg tablets
Allopurinol 300mg tablets

 
   
Febuxostat (Adenuric® )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Febuxostat 80mg tablets
Febuxostat 120mg tablets

Restriction: In line with NICE Guidance

MHRA/CHM advice: Serious hypersensitivity reactions (June 2012)

 
Link  MHRA advice (July 2019)- Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease
Link  NICE TA164: Febuxostat for the management of hyperuricaemia in people with gout
   
10.01.05  Expand sub section  Other drugs for rheumatic diseases
Glucosamine 
View adult BNF  Track Changes
Restricted Drug Restricted
Grey

 

Not approved for inclusion in the North Staffordshire Joint Formulary

NHS England has identified this product as an item that should not be routinely prescribed in primary care (July 2017).

 
Link  NHS England: Items which should not routinely be prescribed in primary care: Guidance for CCGs
   
10.02  Expand sub section  Drugs used in neuromuscular disorders
Nusinersen (Spinraza ®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Restriction: In line with NICE Guidance only

 

 
Link  NICE TA588:Nusinersen for treating spinal muscular atrophy
   
10.02.01  Expand sub section  Drugs which enhance neuromuscular transmission
10.02.01  Expand sub section  Anticholinesterases
Neostigmine  
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Neostigmine bromide 15mg tablets 
Neostigmine metilsulfate 2.5mg/1ml solution for injection ampoules (Hospital only)

 
Link  UKMI Q&A: Converting oral pyridostigmine or neostigmine dose to a parenteral neostigmine dose
   
Pyridostigmine bromide

View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Pyridostigmine bromide 60mg tablets

 
Link  UKMI Q&A: Converting oral pyridostigmine or neostigmine dose to a parenteral neostigmine dose
   
10.02.01  Expand sub section  Acetylcholine-release enhancers to top
Amifampridine (Firdapse®)Black Triangle
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Amifampridine phosphate 10mg tablets

Restriction: In accordance with NHS England prescribing policy

 

Not routinely commissioned by NHS England for Lambert-Eaton myasthenic syndrome (LEMS) except by prior IFR approval.

 
   
Fampridine (Fampyra®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Fampridine 10mg MR tablets

Restriction: In accordance with NHS England prescribing policy

 

Not routinely commissioned by NHS England for multiple sclerosis except by prior IFR approval

 
   
10.02.02  Expand sub section  Skeletal muscle relaxants
Baclofen 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Baclofen 10mg tablets
Baclofen 5mg/5ml oral solution SF

 

Red Intrathecal Injection (Hospital only):
Baclofen 50mcg/ml solution for injection ampoules 
Baclofen 10mg/5ml solution for infusion ampoules
Baclofen 10mg/20ml solution for infusion ampoules

 

 

 
   
Dantrolene sodium  (Dantrium®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Dantrium®- Dantrolene sodium 25mg capsules
Dantrium®- Dantrolene sodium 100mg capsules

 
   
Diazepam 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Diazepam 2mg tablets
Diazepam 5mg tablets
Diazepam 10mg tablets
Diazepam 2mg/5ml oral suspension
Diazepam 2mg/5ml oral solution SF

 

 

 
Controlled Drug Schedule 4 (CD Benz)
   
Tizanidine hydrochloride

View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber E

Tizanidine hydrochloride 2mg tablets
Tizanidine hydrochloride 4mg tablets - EXPENSIVE

Monitor liver function monthly for first 4 months and in those who develop unexplained nausea, anorexia or fatigue.

Link to the ESCA

 

 
   
10.02.02  Expand sub section  Nocturnal leg cramps
Quinine sulfate 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Quinine sulfate 200mg tablets

In hospital, ONLY Quinine sulfate 300mg strength tablets is available

MHRA/CHM advice: reminder of dose-dependent QT-prolonging effects (November 2017)

 
   
10.03  Expand sub section  Drugs for the treatment of soft-tissue disorders and topical pain relief
10.03.01  Expand sub section  Enzymes
Hyaluronidase 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Hyaluronidase 1,500unit powder for solution for injection ampoules

 
   
Collagenase (Xiapex®)
(clostridium histolyticum )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Collagenase 0.9mg powder and solvent for solution for injection ampoules

Restriction: In line with NICE Guidance

 

10/2/2020 - NICE have withdrawn the TA459 guidance because collagenase clostridium histolyticum (Xiapex) is no longer available in the UK.

 
Link  NICE TA459 : Collagenase clostridium histolyticum for treating Dupuytren’s contracture
   
10.03.02  Expand sub section  Rubefacients, topical NSAIDs, capsaicin, and poultices to top
 note 

Rubefacients (excluding topical NSAIDs) should NOT be routinely prescribed in Primary Care and are NON-FORMULARY.

NHS England: Items which should not routinely be prescribed in primary care

10.03.02  Expand sub section  Topical NSAIDs and counter-irritants
Ibuprofen gel 
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Ibuprofen 5% gel

 
   
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG
Blueteq
High Cost Drug Approval System

Traffic Light Status Information

Status Description

Red

Medicines that can only be prescribed within Secondary Care. Examples of medicines which fall into this category are: Certain new medicines and new indications for older medicines where there is at present no experience of use in Primary Care. Medicines or dressings not available or prescribable in Primary Care. Where a medicine has been classified as Amber E, but an approved shared-care guideline is not yet available   

Amber

Medicines which can be prescribed within Secondary Care, but are only suitable for prescribing in Primary Care after specialist referral. There is no need for approved shared care guidelines for medicines in this category. This replaces Amber 2 on the North Staffs Formulary.   

Amber E

Medicines which can be prescribed within Secondary Care, but are only considered suitable for prescribing in Primary Care under an approved shared-care agreement (ESCA) or Rationale for Initiation, Continuation and Discontinuation (RICaD). This replaces Amber 1 on the North Staffs Formulary  

Green

Medicines which can be prescribed in either Primary or Secondary Care.  

Grey

These medicines have been reviewed by the New Medicines Committee and the Area Prescribing Committee and found not to be suitable for inclusion in the Joint Formulary. Inadequate or weak evidence for efficacy No clearly defined local need Lack of long term safety data No perceived benefit over established formulary alternatives Prescribers can consider these medicines where formulary alternatives are unsuitable, ineffective or not tolerated.  

netFormulary